A general routine far computing selected multiple comparisons procedures

Multiple comparisons procedures.

In biomedical research, a common question posed by investigators is whether or not an outcome of interest differs significantly between multiple independent groups of subjects in the study sample. For example, in a randomized clinical trial focusing on differences in a parameter of cardiovascular health such as systolic blood pressure or heart rate that is measured on a continuum, one might mak...

Evaluating the Operating Characteristics of a Class of Closed Multiple Comparisons Procedures: A General Framework

Analytic formulas are developed for various types of power and error rates of some closed testing procedures. The formulas involve non-convex regions that may be integrated with high, pre-specified accuracy using available software. The non-convex regions are represented as a union of hyper-rectangles. These regions are transformed to the unit hypercube, then summed, to create an expression for...

Pairwise multiple comparisons: a model comparison approach versus stepwise procedures.

Researchers in the behavioural sciences have been presented with a host of pairwise multiple comparison procedures that attempt to obtain an optimal combination of Type I error control, power, and ease of application. However, these procedures share one important limitation: intransitive decisions. Moreover, they can be characterized as a piecemeal approach to the problem rather than a holistic...

I I Simultaneous Test Procedures - Some Theory of Multiple Comparisons

Multiple comparisons and association selection in general epidemiology.

In this issue of the journal, Prof. Jon Wakefield provides a contribution to the complex topic of screening genetic associations. My comments here are intended to clarify some points and outline connections of his discussion to broader problems, describing how methods such as Wakefield’s can be appropriate in epidemiology beyond genetic research. I will also comment on a few aspects of his pres...